ABOUT OUR RESEARCH
Our lab has been interested in understanding biogenesis of the primary cilium and its role in diverse cellular processes and human diseases. The primary cilium, distinct from the motile cilia, is a cellular organelle that protrudes from the cellular membrane. The primary cilium is non-motile and solely exists in most types of eukaryote cells. Mainly, we identify novel genes from patients or focus on unknown genes to investigate the association of the primary cilium with diseases. Our lab has been also interested in generating disease animal model using zebrafish and applying the models to screening and/or development of therapeutic chemicals.
SPECIFIC RESEARCH INTERESTS
-
Role of the primary cilium in metabolic disorders
Our lab currently investigates role of the primary cilium in adipogenesis and the effect of its deficit on metabolic disorders including diabetes and obesity.
-
Role of the primary cilium in myopathies
Our lab currently investigates role of the primary cilium in muscle differentiation and the effect of its deficit on myopathies.
-
Role of the primary cilium in cancer
Our lab currently investigates role of the primary cilium in cell cycle regulation, ubiquitin-proteasome system, and mRNA splicing and the effect of its deficit on cancer.
-
Role of the primary cilium in vascular disorders
Our lab currently investigates role of the primary cilium in angiogenesis and the effect of its deficit on vascular disorders including atherosclerosis.
